The spread of the HIV/AIDS pandemic all over the World has reached alarming levels. According to the United Nations, about 40 million people live with HIV today. The most affected continent is Africa, which accounts for 64% of the population living with HIV/AIDS. A recent initiative represents a positive step forward in Africa. The Ugandan Infectious Diseases Institute (IDI) is an important endeavor both locally (as it provides community access to medical treatment and training) and globally (as a best practice example). This case focuses on describing the type of relationships that involved public, private and non-profit organizations in the visioning, planning and building of a large-scale HIV/AIDS treatment center. It stresses the characteristics and role of the partners, with a particular focus on private donors. It details drivers of alliances that could help implementing future partnerships in other regions of the World. Lastly, it suggests issues open and areas for future development.